American Mandrake
Podophyllum peltatum · Berberidaceae
How it looks
American Mandrake (Podophyllum) is a perennial with one or two large umbrella-shaped leaves at the top of the stem. A single white cup-shaped flower hides beneath the leaves. It grows 12-20 in (30-50 cm) tall on the floor of damp woodlands.
Caution — monitor for GI symptoms
All parts of American Mandrake, especially the roots and unripe fruit, contain high levels of podophyllotoxin. Ingestion can quickly cause severe vomiting and diarrhea along with liver damage, so immediate veterinary care is needed.
Guide for parents
An occasional nibble on American Mandrake rarely leads to serious trouble, but the podophyllotoxin it contains irritates the stomach and mucous membranes, causing mild digestive upset. Make a habit of picking up fallen leaves and broken stems the same day, and keep the pot out of your cat's reach. If symptoms last more than 12 hours or your cat's appetite drops noticeably, consult your vet.
If ingested
Contact your nearest vet immediately
- Onset
- 1–4 hours after ingestion
- Symptoms
- Vomiting, diarrhea, liver damage
- Action
- Consult a vet and monitor. Go in immediately if symptoms worsen.
Details
- Scientific name
- Podophyllum peltatum
- Common name
- American Mandrake
- Family
- Berberidaceae
- Toxic parts
- All parts (especially the roots, Unripe fruit)
- Compounds
- Podophyllotoxin
- Source
- ASPCA
Related plants
Same plant family· Berberidaceae
Related guides
Top 10 Flowers Dangerous to Cats — The Ones You See at Florists
Ten flowers you'll commonly find at florists and grocery stores that are toxic to cats. Check before you receive them, and before you bring them home.
Got a Bouquet? What to Do If You Have a Cat
A bouquet is a lovely surprise — but if you live with a cat, there are a few things to take care of right away. From checking what's in the arrangement to choosing the right vase, here's what actually helps, in order.
Why Cats Chew Plants, and How to Stop It
A cat chewing and tearing at plants isn't just mischief — there's an instinct behind it. Once you understand why, the ways to stop it follow naturally.

